Fig. 4: CXCR4/mTOR signaling and ABAT gene expression analysis in cell lines and clinical samples. | Cell Death Discovery

Fig. 4: CXCR4/mTOR signaling and ABAT gene expression analysis in cell lines and clinical samples.

From: ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling

Fig. 4

A ABAT gene expression was analyzed in the GSE19429 dataset. B Expression correlation analysis between ABAT and interferon response-related genes in the GSE19429 dataset. Relative expression of CXCR4, IRF7, IRF9, IRS1, IFNAR1, and IFNGR1 gene in ABAT silenced THP-1 (C) and HL-60 (D) cells. E Correlation analysis of ABAT and CXCR4 gene in MDS samples. F Protein expressions of p-mTOR, mTOR, and CXCR4 in THP-1 and HL-60 cells with ABAT knockdown and HMAs treatment. G CXCR4 gene expression after ABAT overexpression. H IRF7, IRF9, IRS1, IFNAR1, and IFNGR1 gene expressions in the above two cell lines with ABAT overexpression. I Protein expression of p-mTOR, mTOR, and CXCR4 in THP-1 and HL-60 cells after ABAT overexpression and HMAs treatment. Data were represented as mean ± SEM from three biological samples. *P < 0.05, **P < 0.01, ***P < 0.001. Pearson correlation analysis, Student’s t-test (two groups), and one-way ANOVA analysis followed by Dunnett’s test (multiple groups). ns. not significant.

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