Table 2 HOTAIR participates in cell cycle regulation.
From: Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance
Cancer type | Expression | Related drugs | Target | Related genes or pathway | References |
|---|---|---|---|---|---|
Lung cancer | upregulation | cisplatin | / | P21 | [50] |
Lung cancer | upregulation | cisplatin, doxorubicin, and etoposide | / | HOXA1 | [51] |
Lung cancer | upregulation | gefitinib | / | Rb-E2F | [52] |
Lung cancer | upregulation | gefitinib | / | EP4 | [53] |
Gastric cancer | upregulation | cisplatin | miR-126 | PI3K/AKT/MRP1 | [54] |
Gastric cancer | upregulation | doxorubicin and paclitaxel | miR-217 | GPC5/PTPN14 | [55] |
Ovarian cancer | upregulation | paclitaxel | / | CHEK1 | [56] |
Prostate cancer | upregulation | / | / | DNMT1 and EZH2 | [57] |
Myeloma | upregulation | dexamethasone | / | JAK2/STAT3 | [58] |
