Table 7 HOTAIR participates in affecting the drug efflux pump.
From: Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance
Cancer type | Expression | Related drugs | Target | Related genes or pathway | References |
|---|---|---|---|---|---|
Gastric cancer | upregulation | cisplatin | miR-126 | PI3K/AKT/MRP1 | [54] |
Leukemia | upregulation | platinum | / | PI3K/AKT/MRP1 | [34] |
Hepatocellular cancer | upregulation | cisplatin | / | MDR1 | [99] |
Hepatocellular cancer | upregulation | imatinib | miR-145 | P-gp and BCRP | [100] |
Lung cancer | upregulation | cisplatin | / | MRP1, MDR1 and Wnt | [40] |
