Fig. 3: CircPGD sponges miR-16-5p. | Cell Death Discovery

Fig. 3: CircPGD sponges miR-16-5p.

From: Circular RNA circPGD contributes to gastric cancer progression via the sponging miR-16-5p/ABL2 axis and encodes a novel PGD-219aa protein

Fig. 3

A Three public databases estimated circPGD target miRNAs. B qRT-PCR monitored miR-16-5p level after abnormal circPGD level within GC cells. C The dual-luciferase reporter assay demonstrated the existence of binding sites in circPGD with miR-16-5p. D qRT-PCR detected miR-16-5p level within GES-1 and GC cell lines. E Immunofluorescence detected circPGD together with miR-16-5p co-localization within MGC-803 cells, scale bars = 25 μm. F The miR-16-5p expression decreased within tissues showing circPGD upregulation compared with circPGD downregulation. G Pearson correlation analysis found that circPGD was negatively related to miR-16-5p within 50 paired GC samples. *p < 0.05, **p < 0.01, ***p < 0.001.

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