Fig. 7: Mechanistic model of AR-ZIC5 axis-induced metastasis and enzalutamide resistance in PCa.
From: AR-regulated ZIC5 contributes to the aggressiveness of prostate cancer
Following AR/SRC-3/miR-27b-3p axis-induced expression, ZIC5 contributes to PCa metastasis by acting as a transcription factor, to promote TWIST1 transcription and EMT progression, or as a cofactor, to stimulate Wnt/β-catenin signaling and extracellular matrix (ECM) degradation. In parallel, ZIC5 sustains AR expression and signaling, thus favoring the development of enzalutamide resistance.
