Fig. 3: Overexpression of eEF1A proteins activates mTOR signaling. | Cell Death Discovery

Fig. 3: Overexpression of eEF1A proteins activates mTOR signaling.

From: Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

Fig. 3

Representative images of pS6, GFP (viruses), and NeuN staining at the layer V of the right sensorimotor cortex of injured control mice (AAV-GFP injection) (A–A””); injured eEF1A1-overexpressing (OE) mice (B–B””); injured eEF1A2-OE mice (C–C””); injured eEF1As-OE mice (D–D””); and injured PTEN cKO mice serving as a positive control (E–E”). F Quantification of pS6 immunoreactivity. Scale bars: 50 μm. Control, 12 mice; eEF1A1, 10 mice; eEF1A2, 10 mice; eEF1As, 8 mice; PTEN cKO, 4 mice; 20 cells quantified per mouse. Stats: One-way ANOVA with Kruskal–Wallis Test. Bars show mean ± SEM. ****p < 0.0001.

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