Fig. 1: The WWP2 expression differences exist in different period ALL patients and normal control people, and knockout WWP2 inhibits ALL xenograft tumor growth. | Cell Death Discovery

Fig. 1: The WWP2 expression differences exist in different period ALL patients and normal control people, and knockout WWP2 inhibits ALL xenograft tumor growth.

From: The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

Fig. 1

A The WWP2 relative expression levels of bone marrow samples of newly diagnosed ALL patients (n = 30), CR ALL patients (n = 30), relapse ALL patients (n = 7) and normal control people (n = 10) were evaluated by normalized fold expression by RT-qPCR. Data were shown as mean ± standard deviation (SD) (*p < 0.05, **p < 0.01, ***p < 0.001; unpaired Student’s t test). B-E The photos of nude mice and xenograft tumor excised showed the growing differences of xenograft tumors volume and weight at the end of observation period in NC + Nacl group (black), NC + Dox group (red), shWWP2 + Nacl group (blue) and shWWP2 + Dox group (green). Data were shown as mean ± SD, the line chart illustrates the variation of xenograft tumor volume growing in different groups (n = 5; *p < 0.05; one-way ANOVA with Bonferroni’s post-hoc test) and the scatter chart illustrates the weight of xenograft tumors excised of different groups (n = 5; *p < 0.05, **p < 0.01, ***p < 0.001; unpaired Student’s t test, two-way ANOVA with Bonferroni’s post-hoc test).

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