Fig. 5: Reduced MAPK pathway signaling decreases aggressiveness of PC-overexpressed PTC cells. | Cell Death Discovery

Fig. 5: Reduced MAPK pathway signaling decreases aggressiveness of PC-overexpressed PTC cells.

From: Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake

Fig. 5

A Cell proliferation abilities of PC-overexpressed TPC-1 and KTC-1 cells with siRNAs knockdown of ERK1/2 signaling and B cell proliferation abilities of PC-overexpressed TPC-1 and KTC-1 cells with SCH772984 treatment detected by CCK8 assay. C Colony-formation ability of PC-overexpressed TPC-1 and KTC-1 cells with siRNAs or SCH772984 knockdown of ERK1/2 signaling. Metastatic abilities of PC-overexpressed TPC-1 and KTC-1 cells with siRNAs or SCH772984 knockdown of ERK1/2 signaling detected by D scratch assay and E Transwell migration and invasion assays, respectively. ***p < 0.001, **p < 0.01, *p < 0.05. Representative photomicrographs taken at 100× magnification. Results expressed as mean ± SD of three independent experiments and shown in histograms on the right.

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