Fig. 6: ZY-444 inhibits aggressiveness of PTC cells. | Cell Death Discovery

Fig. 6: ZY-444 inhibits aggressiveness of PTC cells.

From: Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake

Fig. 6

A IC50 of TPC-1 and KTC-1 cells analyzed by CCK8 assay. B Effect of ZY-444 1 µM on PC enzymatic activity. Metastatic abilities of PC-overexpressed TPC-1 and KTC-1 cells with 1 µM ZY-444 treatment detected by C scratch assay and D Transwell migration and invasion assays, respectively. ***p < 0.001, **p <p < 0.01, *p < 0.05. Representative photomicrographs taken at ×100 magnification. Results expressed as mean ± SD of three independent experiments and shown in histograms on the right.

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