Fig. 1: The enrichment of CAFs is associated with tumor progression and cancer stemness in RCC.

A Representative images of IHC staining of α-SMA and CD105 in RCC tissues (n = 141). B IHC score of α-SMA and CD105 in low stage (I–II) (n = 111) and high stage (III–IV) (n = 30), the data are shown as the mean ± SEM; C Pearson’s correlation scatter plot of IHC score of α-SMA and CD105 (n = 141). P value between two groups was obtained by Unpaired t test. *P < 0.05; **P < 0.01.