Fig. 10: A schematic diagram of the mechanism.

CAFs secreted exosomal miR-181d-5p to RCC cells, suppressed the expression of RNF43, activated Wnt/β-catenin signaling pathway, thus promoted cancer stemness and tumor progression.
CAFs secreted exosomal miR-181d-5p to RCC cells, suppressed the expression of RNF43, activated Wnt/β-catenin signaling pathway, thus promoted cancer stemness and tumor progression.