Fig. 4: PTPN7 is a direct target of miRNA-592. | Cell Death Discovery

Fig. 4: PTPN7 is a direct target of miRNA-592.

From: Extracellular vesicles microRNA-592 of melanoma stem cells promotes metastasis through activation of MAPK/ERK signaling pathway by targeting PTPN7 in non-stemness melanoma cells

Fig. 4

a Target genes of miR-592 were predicted by intersection of multiple databases, p < 0.05. b, c KEGG and GO enrichment analysis were performed for the predicted target genes of miR-592 (DAVID). d Target genes of miR-592 expression were verified in MPCs and MSCs. e Target genes of miR-592 expression were verified in miR592-OE-MPCs and NC-MPCs. f Higher PTPN7 expression is significantly associated with better survival (TCGA database). g, h PTPN7 expression was regulated by miR-592. i–k luciferase assay confirmed that PTPN7 was the direct gene target of miR592 (ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001).

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