Fig. 2: Loss of LXN in mice significantly promotes the growth of cancer cells by remodeling tumor microenvironment in the subcutaneous tumor models. | Cell Death Discovery

Fig. 2: Loss of LXN in mice significantly promotes the growth of cancer cells by remodeling tumor microenvironment in the subcutaneous tumor models.

From: Loss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice

Fig. 2

A Experimental scheme for subcutaneous tumor assay. B, C MC38 cells (B) and LLC cells (C) were inoculated into the armpits of WT and LXN KO mice. The growth of the implanted tumor size was measured every 3 days and the tumor weight was measured at the end point (n = 6 mice). D Flow cytometry analysis of macrophages (F4/80+CD11b+) and the different subsets (M1, CD16/32+ CD206−; M2, CD16/32−CD206+) in tumor from WT and LXN KO mice. E Flow cytometry analysis of T cells (CD3+B220−) and the different subsets (CD8+T cell and CD4+T cell) in tumor from WT and LXN KO mice. Data are representative of three independent experiments. *P < 0.05, **P < 0.01, n.s. no significance.

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