Table 2 Paracrine effectors of MSCs in the regulation of macrophage polarization.
From: Inflammation in myocardial infarction: roles of mesenchymal stem cells and their secretome
Factors | Effectiveness | Mechanisms | Reference |
|---|---|---|---|
TSG6 | Induce M2 macrophages polarization | Suppress NF-κB pathway activation | [42] |
TSG6 | Inhibit macrophages migration | Bind to CD44 | [55] |
PGE2 | Convert macrophages into regenerative phenotype | Not mentioned | [56] |
IL-33 | Enhance M2 macrophages polarization | Not mentioned | [57] |
miR-182 | Convert M1 macrophages to M2 phenotype | Inhibit TLR4 expression | [45] |
