Fig. 8: Global deregulated proteins in Strip2 KD ESCs (SILAC).
From: Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
A Number of proteins up- or downregulated in Strip2−-ESCs vs Strip2+-ESCs, 4-day Strip2--EBs vs 4-day Strip2+-EBs, and 16-day Strip2−-EBs vs 16-day Strip2+-EBs. B Visualization of K-means clustering of 3 501 differentially expressed proteins (0.5-fold change in expression), using a Euclidean distance measurement and k = 4 group clusters. The replicates are displayed on the vertical axis, with proteins on the horizontal axis. Z score signal intensities are depicted, using a color gradient. The heatmap indicates high expression levels in red, intermediate in dark black, and low expression levels in green. C Metascape analysis of the deregulated proteins in clusters 1 and 3 (Strip2−-ESCs, 4-day EBs and 16-day EBs vs Strip2+-ESCs, 4-day Strip2+-EBs and 16-day Strip2+-EBs).
