Fig. 4: Significant biological characteristics and gene expression patterns representing four time-points.
From: Stepwise molecular mechanisms responsible for chemoresistance in bladder cancer cells
A Biological characteristics at each time-point. The size of the symbol indicates the number of genes on each term. The diamond and circle shapes indicated downregulation and upregulation, respectively. The darkness indicates the degree of FDR. B Gene expression patterns associated with significantly identified biological characteristics at each time-point. The colors in the heatmap reflect relatively high (red) and low (blue) expression CPM values. C Schematic graph of molecular changes in gemcitabine resistance. The top indicates the underlying phenomenon related to gemcitabine resistance. The bottom panel shows a graph of the signaling pathways that induce gemcitabine resistance. FDR false discovery rate, ER endoplasmic reticulum, EMT epithelial to mesenchymal transition, MoA mechanism of action.
