Fig. 2: Combining tautomycin and enzalutamide synergistically decreased AR protein level and inhibited AR downstream genes expression.

A, B The protein levels of AR, PSA, and GAPDH were detected using Western blot in LNCaP (A) and C4-2 (B) cells, and quantitative levels are shown on the left. C, D The mRNA levels of KLK3 and TMPRSS2 were explored using qRT-PCR in LNCaP (C) and C4-2 (D) cells with indicated treatment. #Synergy by bliss-independent analysis.