Fig. 6: Effect of PEVs on calcium-induced apoptosis in Jurkat cell. | Cell Death Discovery

Fig. 6: Effect of PEVs on calcium-induced apoptosis in Jurkat cell.

From: Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

Fig. 6

A Representative dot plots of Jurkat cell apoptosis analyzed by flow cytometry. The signal associated to propidium iodide (PI) and Annexin V-APC are reported on the y- and x-axis, respectively. B Quantification of apoptosis as the percentage of cells in the Q2 (late apoptosis) and Q3 (early apoptosis) quadrants. The data are representative of the mean ± SD of four independent experiments. The results of the statistical analysis of the differences between samples treated with A23187 (gray bars) and respective controls (white bars) are indicated by ^^^ (p < 0.0001). The statistical significance of the differences between PEVs-treated samples and respective controls is indicated with the asterisks (*p < 0.05; ***p < 0.0001). C Quantification of necrotic cells as the percentage of cells in the Q1 quadrant. The data are representative of the mean ± SD of three independent experiments with *p < 0.05. The statistical significance between samples treated with A23187 (gray bars) and respective controls (white bars) are indicated by as ^ (p < 0.05) and ^^ (p < 0.001).

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