Fig. 1: Reduced expression of CDO1 in GC tissue is indicative of poor prognosis. | Cell Death Discovery

Fig. 1: Reduced expression of CDO1 in GC tissue is indicative of poor prognosis.

From: Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells

Fig. 1

A CDO1 mRNA level was examined in 30 paired GC and adjacent normal tissues, showing that it decreased in GC specimens relative to normal ones. B Analysis of CDO1 mRNA expression in one independent GC patient cohort (GSE29272) demonstrated that it was lower in GC samples than in normal counterparts. C IHC showed that CDO1 staining was stronger in normal gastric mucosa than in GC tissues. The representative images of one pair of tissues are presented here. Scale bars, 400 μm and 100 μm respectively. D Statistical analysis showed 50% of normal samples with high CDO1 protein expression while around 20% of GC tissues with high CDO1 protein level (N = 130). E Kaplan–Meier analysis of overall survival in GC patients with high or low CDO1 protein level showed that patients with higher CDO1 expression had better survival rate. The high or low expression of CDO1 in Kaplan–Meier analysis was stratified by median CDO1 protein level from IHC staining quantifications. **p < 0.01, ***p < 0.001.

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