Fig. 3: The anti-proliferation function of CDO1 is in an enzymatic activity-dependent manner. | Cell Death Discovery

Fig. 3: The anti-proliferation function of CDO1 is in an enzymatic activity-dependent manner.

From: Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells

Fig. 3

A The expression efficiency of CDO1WT and CDO1Y157F was confirmed via immunoblots in MKN45 (left panel) and NCI-N87 (right panel) cells. B CDO1Y157F, unlike CDO1WT, did not attenuate the growth of MKN45 (left panel) or NCI-N87 (right panel) cells in vitro, as indicated by CCK-8 assay at the indicated time points (N = 6, mean ± SD). C Tumor xenografts model showed that CDO1Y157F could not inhibit the growth of MKN45 cells in vivo. The tumor masses from the indicated three groups were photographed and weighed (N = 10 mice per group). ***p < 0.001, n.s. means no significance.

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