Fig. 1: Doxorubicin induces IRF3 covalent dimers.
From: Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
A, B Western blot analysis of H2AX and γH2AX expression in A375 cells treated with doxorubicin for 6, 16, and 24 h. GAPDH was used as loading control. (n = 3; means ± SEM; ***p < 0,001). C, D Western blot analysis of TBK1 and STING protein expression in A375 treated with doxorubicin. Actin was used as loading control. (n = 3; means ± SEM; p = ns). E Western blot and densitometric analysis of IRF3 levels in A375 treated with doxorubicin. Tubulin was used as loading control. (n = 3; means ± SEM; ***p < 0.001).
