Fig. 6: TGFβ2 and RAGE represent two major targets of KDM5C to repress trophoblast proliferation and invasion. | Cell Death Discovery

Fig. 6: TGFβ2 and RAGE represent two major targets of KDM5C to repress trophoblast proliferation and invasion.

From: Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion

Fig. 6

HTR-8 cells stably transfected with either control vector or KDM5C overexpression vector were additionally lentivirally transduced with control-GFP, TGFβ2-GFP, or RAGE-GFP, and the cell cycle status was then analyzed using flow cytometry (A, B), and the invasive ability of HTR-8 cells was determined using Image-Pro Plus 6.0 software (C, D); scale bar = 200 μM; B, n = 3 for each group; D, n = 10 for each group. The ANOVA test was used to evaluate the statistical significance; ***p < 0.001.

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