Fig. 7: Schematic illustration of TAZ in MSCs and its mechanism of interaction with BMP/Smad, MAPKs, and Wnt/β-catenin signaling. | Cell Death Discovery

Fig. 7: Schematic illustration of TAZ in MSCs and its mechanism of interaction with BMP/Smad, MAPKs, and Wnt/β-catenin signaling.

From: TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9

Fig. 7

The BMP pathway is activated by BMP9. BMPR-I activates Smads and phosphorylates Smad to form a Smad1/5/8-Smad complex, which is eventually transported into the nucleus and to initiates the transcription of downstream osteogenic-related genes. Meanwhile, BMP pathway promotes β-catenin expression and MAPK signaling pathway phosphorylation. The expression Ad-TAZ recombinant adenovirus produces TAZ and promotes classical Smad1/5/8, Wnt/β-catenin, and MAPKs signaling pathways induced by BMP9.

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