Fig. 2: Different concentration of PGD2 displayed distinct effects on DLBCL cell proliferation. | Cell Death Discovery

Fig. 2: Different concentration of PGD2 displayed distinct effects on DLBCL cell proliferation.

From: PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations

Fig. 2

A GO analysis of CRTH2 associated genes (p < 0.05) based on GSE31312 database indicated the association between CRTH2 and tumor development. B The treatment with PGD2 (0.6 ng/mL), similar concentration to serum PGD2, promoted cell proliferation. C, D High-concentration PGD2 dose-dependently decreased cell proliferation and c-myc expression in DLBCL cells. E Low-concentration PGD2 increased the expression level of CRTH2 while high-concentration PGD2 significantly decreased it. The expression of CRTH2 in DLBCL cells without drug treatment was adjusted to 1. F AZD1981 (AZD), the CRTH2 inhibitor, rescued the pro-proliferation effects of low-concentration PGD2, but not the anti-proliferation effects of high-concentration PGD2 in DLBCL cells. DLBCL cells were treated with drugs for 48 h. Data are shown as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001.

Back to article page