Fig. 3: High-concentration PGD2 regulated the cell cycle, apoptosis, and invasion of DLBCL cells. | Cell Death Discovery

Fig. 3: High-concentration PGD2 regulated the cell cycle, apoptosis, and invasion of DLBCL cells.

From: PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations

Fig. 3

After the treatment with high-concentration PGD2 for 48 h, A–C High-concentration PGD2 induced G0/G1 cell cycle arrest and decreased the expression of Cyclin D1 and CDK2 in DLBCL cells. D–F High-concentration PGD2 induced cell apoptosis (D representative images and E statistic results) and influenced the expression of apoptosis associated proteins. G, H High-concentration PGD2 suppressed cell invasion and the expression of zeb1 and vimentin. Data are shown as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001.

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