Fig. 5: HDAC inhibitors regulated the expression and effects of PGD2 and CRTH2 in DLBCL cells. | Cell Death Discovery

Fig. 5: HDAC inhibitors regulated the expression and effects of PGD2 and CRTH2 in DLBCL cells.

From: PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations

Fig. 5

A, B The expression level of PTGDS and the production of PGD2 were decreased by vorinostat (SAHA) and panobinostat (LBH589) in DLBCL cells. C SAHA and LBH589 increased the expression of CRTH2 in DLBCL cells. The expression of CRTH2 in cells without drug treatment was adjusted to 1. D, E The treatment of AZD1981 (AZD) and high-concentration PGD2 enhanced the cytotoxicity of HDAC inhibitors in LY1 and LY3 cells. F Mechanism diagram summarized that PGD2-CRTH2 enhanced tumor progression and high-concentration PGD2 exhibited potent anti-tumor activities through ROS-dependent DNA damage in DLBCL. Cells were treated with drugs for 48 h. Data are shown as the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001.

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