Fig. 5: Liver resident CD8+ T cell apoptosis in the LCP period seems to promote fibrosis via protecting HSCs from apoptosis. | Cell Death Discovery

Fig. 5: Liver resident CD8+ T cell apoptosis in the LCP period seems to promote fibrosis via protecting HSCs from apoptosis.

From: Hepatocyte growth factor-mediated apoptosis mechanisms of cytotoxic CD8+ T cells in normal and cirrhotic livers

Fig. 5

A–C Immunofluorescence staining for fibrotic/cirrhotic liver tissue-resident α-SMA+ HSCs (green) at 3 (A, a box) and 10 weeks (B, a box) post-DEN and quantification (C). Scale bar = 200 µM, n = 6. D–F TUNEL staining (red) to target α-SMA+ HSCs labeled by red fluorescence (red) at 3 (D, arrows) and 10 (E, arrows) weeks post-DEN and quantification of the numbers of double-stained TUNEL and α-SMA+ cells (F). Scale bar = 200 µM, n = 6/each staining. At least three independent experiments were performed, and the data are presented as the means ± SDs; *p < 0.05 vs. 10 weeks post DEN (Student’s t test).

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