Fig. 4: AST activated autophagy initiation in hippocampal neurons of APP/PS1 mice. | Cell Death Discovery

Fig. 4: AST activated autophagy initiation in hippocampal neurons of APP/PS1 mice.

From: Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

Fig. 4

A–C Representative immunofluorescent staining of LC3B/p62/Beclin-1, NeuN, and DAPI in hippocampal neurons of mice. Scale bar = 100 μm. D Representative bands of LC3BII/LC3BI, p62, and Beclin-1 in the hippocampus of mice by western blot (WB) detection. E–G Statistical analysis of LC3BII/LC3BI, p62, and Beclin-1 proteins in the hippocampus of mice. Data were presented as mean ± SD, n = 3/group. **p < 0.01 and ***p < 0.001 vs WT group, #p < 0.05, ##p < 0.01 and ###p < 0.001 vs APP/PS1 group.

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