Fig. 5: AST promoted autophagosome formation and the initiation of autophagic lysosomal phase in hippocampal neurons of APP/PS1 mice. | Cell Death Discovery

Fig. 5: AST promoted autophagosome formation and the initiation of autophagic lysosomal phase in hippocampal neurons of APP/PS1 mice.

From: Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

Fig. 5

A–C Representative immunofluorescent staining of ATG5/ATG12/LAMP-1, NeuN, and DAPI in hippocampal neurons of mice. Scale bar = 100 μm. D, E Representative bands of ATG5, ATG12, and LAMP-1 in the hippocampus of mice by WB detection. F–H Statistical analysis of ATG5, ATG12, and LAMP-1 proteins in the hippocampus of mice. Data were presented as mean ± SD, n = 3/group. **p < 0.01 vs WT group, #p < 0.05, ##p < 0.01 vs APP/PS1 group.

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