Table 1 Part of the components of Chinese herbal medicines for the treatment of AD.
From: Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice
Traditional Chinese medicine | Partial molecule name | Mechanism of action | Reference |
|---|---|---|---|
Acori tataninowii Rhizoma | 8-Isopentenyl-kaempferol, Cycloartenol, beta-asarone, Astragalin | promoted the growth of neurons as well as the growth and connection of neuronal synapses | [51] |
Eucommiae Cortex | protocatechuic acid, vanillic acid, Trochol, Astragalin | involved in the activation of the cholinergic system via inhibition AChE and TBARS activities | [52] |
Paeoniae Radix Alba | propyl (2 R)-2-hydroxypropanoate, gallotannin, paeonoside, Astragalin | prevented oxidative injury and mitochondrial dysfunction | [53] |
Carthami Flos | o-xylene, p-xylene, Arachic acid, Astragalin | inhibited oxidative stress damage and cell apoptosis | [54] |
Forsythiae Fructus | vanillic acid, Cymol, citral, Astragalin | inhibited NF-κB signaling pathway | [55] |
Achyranthis Bidentatae Radix | poriferasta-7,22E-dien-3beta-ol, 3-epioleanolic acid, Astragalin | reduced the accumulation of advanced glycation end products | [56] |
Granati Pericarpium | Officinalisin, Punicalin, cyclohexane, Astragalin | inhibited nuclear factor of activated T-cell activity and microglial activation | [57] |
Epimrdii Herba | (L)-alpha-Terpineol, isoliquiritigenin, Astragalin | promoted neuronal cell activity, preserved mitochondrial and synaptic functional proteins | [58] |
