Fig. 5: Comparative analysis of time-course transcriptomics data show decreases of T cell gene expression in PD.
From: Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease
A, F A total 46 core deregulated genes with an adjusted p-value ≤0.05 and a median log2 FC ≥0.5 or ≤−0.5 for the comparison between PD and HC groups showed a significant RNA increase at more than one time-point of the T cell activation course. One core gene (VCAN1) showed significant RNA alternation during the T cell activation time-course. Corresponding FDR adjusted p-values of the analyzed time-points (0, 2, 4, 8, 12, and 24 h) are depicted for the comparison between PD and HC groups. B–E, G Exemplary log2 time-course expression data of ADAMTS10, BRCA1, LOC100505585, MCM10, and of VCAN1 are shown for PD and HC groups. The boxes show the range from the 25th to 75th percentiles with the median indicated by horizontal lines within the boxes and the total expression ranges per by whiskers. Significant differences between PD and HC at the time points are indicated by darker colors.
