Fig. 1: Experimental design.
From: Repositioning linifanib as a potent anti-necroptosis agent for sepsis
For virtual screening of sepsis drugs, sepsis-related signaling pathways and datasets were retrieved from a public database. DEGs were extracted from sepsis-related microarray data from GEO. Sepsis-related gene expression data and gene expression profiles in the L1000 database were used to calculate therapeutic scores to obtain top candidate compounds. In experimental validation, FDA-approved drug linifanib was shown to have therapeutic effects in cellular and animal models of necroptosis.
