Fig. 6: Linifanib protects mice against SIRS induced by TNF-α.
From: Repositioning linifanib as a potent anti-necroptosis agent for sepsis
Ten-week-old male C57BL/6 J mice were pretreated with or without linifanib (50 mg·kg-1 gavage) or Nec-1 (30 mg·kg-1 gavage) for 30 min, and then SIRS was induced with mTNFα (5 μg/ mice i.v.). Control mice received an equal amount of vehicle before mTNF-α challenge. A The survival curve and B the mouse body temperatures (means ± SEM) of linifanib-treated mice (n = 10 for each group), Nec-1-treated mice (n = 10 for each group), and vehicle control mice (n = 10 per group) are shown. The results are presented as the mean value ±S.D. **p < 0.01, ****p < 0.0001. C After SIRS induction for 6 h, the IL-6 levels of lung tissues were determined by real-time PCR. Results represent the mean±S.D. from six mice. **p < 0.01, significantly different from vehicle control group.
