Table 1 Some reported proteins playing a role in organelle crosstalk.

Protein	Location	Function	References
VPS13	ER, mitochondria	Iron regulation	[33]
DRP1	ER, mitochondria	Control mitochondria division	[41]
NLRP3	ER	Modulate innate response	[34, 35]
CARD	Mitochondria	Modulate innate response	[34, 35]
REEP1	ER	Affect endoplasmic reticulum amplification	[36]
CAV1	ER, mitochondria	Cholesterol transport	[37]
PERK	ER, mitochondria	Cell death	[38, 43]
MFN2	ER, mitochondria	Affect mitochondrial morphology	[43, 51]
VMP1	ER	Autophagy	[39, 44]
VDAC	Mitochondria	The channel protein of Ca²⁺ transmission	[62]
IP3R	ER	The channel protein of Ca²⁺ transmission	[64, 65]
RTN	ER	Affect formation of the ER-MITO contact	[40]
AMPK	Mitochondria	Sensor of energy status	[72]
GSL	Lysosomal	Efficient lipoprotein modules	[84]
VAPA	Plasma membrane, intracellular vesicle	Affect vesicle transport, membrane fusion	[91]
ACBD5	Peroxisome	ER peroxidase contact site	[88, 91]
PEX	Peroxisome	Affect protein import into peroxisomes and peroxisome biogenesis	[90]
ORD	ER, Golgi apparatus	Part of the PH domain	[94]
NSF	Golgi apparatus	Reduce protein transport speed	[96]
ORP1L	Lysosome	Allow lysosome and ER to juxtapose	[100]
TFEB	Lysosome	Enable DNA-binding transcription factor activity	[108]

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