Fig. 1: MLKL depletion protected livers against IR injury. | Cell Death Discovery

Fig. 1: MLKL depletion protected livers against IR injury.

From: MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury

Fig. 1

WT mice were subjected to liver IR model or sham procedure. Liver tissues and primary hepatocytes were collected at 6 h post reperfusion. A Western blot analysis of MLKL and GAPDH in liver tissues. B Immunofluorescence staining of DAPI (blue) and MLKL (red) in liver tissues. C Western blot analysis of MLKL and GAPDH in primary hepatocytes. WT and MLKL KO mice were subjected to liver IR model or sham procedure. Liver tissues, blood samples were collected at 6 h post reperfusion. D, E Serum levels of ALT and AST. F H&E‐staining of liver sections; Suzuki scores based on H&E. n = 5 mice/group. All results represent at least two independent experiments. Values were expressed as mean ± SD. *p < 0.05.

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