Fig. 3: Molecular signal pathway in MK801 regulated dysfunction of HUVEC induced by LPS. | Cell Death Discovery

Fig. 3: Molecular signal pathway in MK801 regulated dysfunction of HUVEC induced by LPS.

From: NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway

Fig. 3

A Representative of western blotting images and B analysis of phosphorylation of Erk1/2 (p-Erk1/2) and CaMKII (p-CaMKII), and expression of CaM, MCU, MCUR, and TLR4 in HUVECs exposed to LPS in the presence or absence of different concentrations of MK801. (Data are presented as mean ± SEM, ***P < 0.001, **P < 0.01, *P < 0.05 vs. Control; ###P < 0.001, ##P < 0.01, #P < 0.05 vs. LPS).

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