Fig. 7: MK801 ameliorated LPS-induced vascular permeability in mice. | Cell Death Discovery

Fig. 7: MK801 ameliorated LPS-induced vascular permeability in mice.

From: NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway

Fig. 7

A EB extravasation in C57/BL6 mice treated with vehicle, LPS (5 mg/kg, i/p), or LPS plus MK-801 for 12 h. Evans blue dye (30 ml/kg, i/v) was injected 2 h before the termination of the experiment. B Wet/dry ratio of lungs from the control group, LPS-induced mice group, and LPS-induced mice treated with MK-801. C The schematic image of the present finding. (Data are presented as mean ± SEM, ***P < 0.001, **P < 0.01, *P < 0.05 vs. Control; ##P < 0.01, #P < 0.05 vs. LPS).

Back to article page