Fig. 4: Downregulation of KLF10 in survived tubular cells was reversed as the integrity of injury 3D renal tubules recovered in vitro. | Cell Death Discovery

Fig. 4: Downregulation of KLF10 in survived tubular cells was reversed as the integrity of injury 3D renal tubules recovered in vitro.

From: Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis

Fig. 4

A Diagram detailing cisplatin treatment regime in 3D renal tubular model. B Representative immunoblot analysis of KLF10 and PCNA in model of Fig. 4A. ACTIN served as the standard. C Diagram detailing the change in flurescent color of Fucci-cell during different stages of cell cycle. D Diagram detailing puromycin treatment regime in 3D renal tubular model. E Representative immunoblot analysis of KLF10 and PCNA in model of Fig. 4D. ACTIN served as the standard. F Fluorescence images of 3D survived tubular repair model according to the treatment in Fig. 4D, reflecting the forming integrity of survived tubular cells (LM and GFP) and proliferative activity (Fucci-overall, Merge and Fucci).

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