Fig. 2: Ip3r1 deletion in skeletal muscle leads to lower muscle weight. | Cell Death Discovery

Fig. 2: Ip3r1 deletion in skeletal muscle leads to lower muscle weight.

From: Lack of adipocyte IP3R1 reduces diet-induced obesity and greatly improves whole-body glucose homeostasis

Fig. 2

A mRNA expression levels of Ip3r1 in skeletal muscle (TA and GAS), adipose tissues (eWAT and iWAT), heart, liver, spleen, lung and kidney (n = 6). B, C Relative mRNA expression levels of Ip3r2 and Ip3r3 in TA and GAS isolated from WT and Ip3r1MKO mice (n = 5). D, E Body weight curve of WT and Ip3r1MKO female and male mice (n = 10). F Fat mass and (G) lean mass of adult WT and Ip3r1MKO female and male mice measured by the nuclear magnetic resonance system (n = 4–6). H, I Representative images of size and TA, EDL, GAS and Sol muscles in adult WT and Ip3r1MKO mice. J Muscle weight of adult WT and Ip3r1MKO mice (n = 5). K H&E staining of TA muscles and (L) frequency histogram of fiber cross-sectional area (n = 6). Scale bar = 100 µm. All data were analyzed by two-tailed unpaired Student’s t test and presented as means ± SEM. *P < 0.05, **P < 0.01.

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