Fig. 3: Role of IP3R1 in skeletal muscle in controlling systemic glucose homeostasis of mice maintained on chow diet (CD) or high-fat diet (HFD). | Cell Death Discovery

Fig. 3: Role of IP3R1 in skeletal muscle in controlling systemic glucose homeostasis of mice maintained on chow diet (CD) or high-fat diet (HFD).

From: Lack of adipocyte IP3R1 reduces diet-induced obesity and greatly improves whole-body glucose homeostasis

Fig. 3

A GTT (2 g/kg glucose, i.p.), B ITT (1U/kg insulin, i.p.), C blood glucose levels, D plasma insulin levels, and E plasma C-peptide levels after 8 wk of CD feeding (n = 7–10). F Growth curve of body weight during the 8 wk of HFD feeding (n = 10-11). G Muscle weight, H muscle weight percentage, I GTT (2 g/kg glucose, i.p.), J ITT (1U/kg insulin, i.p.), K blood glucose levels, L plasma insulin levels, and M plasma C-peptide levels after 8 wk of HFD feeding. N = 6–9 for G and H, n = 10-11 for I and J, and n = 10 for K–M. All Data are presented as means ± SEM. *P < 0.05, **P < 0.01. A, B, I, J: two-way ANOVA followed by Bonferroni’s post hoc test; C–H, K–M: two-tailed unpaired Student’s t test.

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