Fig. 3: TLR2/GPCR are crucial for Ef.LTA/NaB-induced inflammasome activation. | Cell Death Discovery

Fig. 3: TLR2/GPCR are crucial for Ef.LTA/NaB-induced inflammasome activation.

From: Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition

Fig. 3

PMA-differentiated THP-1 cells were pre-treated with the TLR2-neutralizing antibody or its isotype control antibody (A), PTX (B), TPCK, or BAY 11-7082 (C) for 1 h and subsequently co-stimulated with Ef.LTA (10 μg/ml) and NaB (10 mM) for an additional 6 h. IL-1β expression in the culture supernatants was measured by ELISA. p < 0.05. D The cells were subjected to MTT assay to determine cell viability. VC denotes vehicle control (DMSO).

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