Fig. 4: Conditional deletion of Mincle from macrophages inhibits IMQ-induced psoriasis in Mincleflox/flox/Lyz-cre+/+ mice.
From: Macrophages mediate psoriasis via Mincle-dependent mechanism in mice
A Psoriasis-like skin lesions induced by miquimod in WT and Mincle-KO mouse model. B Representative images of immunofluorescence staining of F4/80 and Mincle in WT and Mincle-KO mouse model. C H&E staining showed the histopathology of skin in WT and Mincle-KO mouse model. D Representative images of immunofluorescence staining of keratin-17 in WT and Mincle-KO mouse model. E Baker score of H&E staining. F Western blot showed the protein levels of Mincle and Keratin-17 in each group. G Western blot showed the protein levels of IL-1β, IL-6 and TNF-α in each group. H Real-time PCR detected the mRNA expression of Keratin-17, Intergrin β1, CXCL9, iNOS, IL-1β, IL-6 and TNF-α in each group. n = 4 in each group. ***P < 0.001 vs. WT-IMQ group.
