Fig. 4: Strategies for modulating ferroptosis to overcome anthracycline-based chemoresistance. | Cell Death Discovery

Fig. 4: Strategies for modulating ferroptosis to overcome anthracycline-based chemoresistance.

From: The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity

Fig. 4

The main four specific areas include nanomedicines carrying both ferroptosis-inducing agents and anthracycline-based chemotherapeutic agents, traditional and novel ferroptosis-targeting small molecules, plant-derived natural compounds represented by dihydroartemisinin, and the recently discovered propofol-related drugs. GSH glutathione, GPX4 glutathione peroxidase 4, ROS reactive oxygen species, DMT1 divalent metal transporter 1, Tf transferrin, TfR transferrin receptor, PUFA polyunsaturated fatty acid, PUFA-PE polyunsaturated phosphatidylethanolamines.

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