Fig. 1: Immunosuppressive glioma-associated macrophage (GAMs)-related genes were upregulated in glioblastoma multiforme (GBM) compared with low-grade glioma (LGG). | Cell Death Discovery

Fig. 1: Immunosuppressive glioma-associated macrophage (GAMs)-related genes were upregulated in glioblastoma multiforme (GBM) compared with low-grade glioma (LGG).

From: MiR-146a-5p deficiency in extracellular vesicles of glioma-associated macrophages promotes epithelial-mesenchymal transition through the NF-κB signaling pathway

Fig. 1

A The mRNA expression of the immunostimulatory genes CD80, CD86, IFNG, IL1B, NF2, TNF, and TLR4 in LGG and GBM in The Cancer Genome Atlas (TCGA) database was analyzed. B The mRNA expression of the immunosuppressive genes CCL2, CCL5, CD163, IDO1, IL10, MSR1, and TGFB in LGG and GBM in TCGA was analyzed. C The overall survival (OS) and disease-free survival (DFS) of GBM and LGG patients in TCGA with differential expression of CD80, CD86, IFNG, IL1B, NF2, TNF, and TLR4 was analyzed with GEPIA 2.0. D The OS and DFS of patients with GBM and LGG in TCGA with differential expression of CCL2, CCL5, CD163, IDO1, IL10, MSR1, and TGFB was analyzed with GEPIA 2.0. E The levels of TLR4, CD86, CD163, and MSR1 in GBM (n = 4) and LGG (grade II and III gliomas, n = 8) clinical samples were determined by immunohistochemical (IHC) staining and quantitative analysis. Scale bar = 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001.

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