Fig. 6: Mitophagy enhances the killing effect of ionizing radiation in vivo.
From: Ionizing radiation triggers mitophagy to enhance DNA damage in cancer cells
C57BL/6 mice were implanted subcutaneously with wild-type, ParkinKO, and ParkinOE B16 or S91 cells (A). When the tumor reached about 50 mm3, it was irradiated with 4 Gy X-rays (B). The expression of Ki67 and phosphorylated ATR, ATM, and BRCA1 was examined using immunohistochemical staining (C). Tumor growth was monitored every two days, and the survival of mice was compared under various treatments (D–I).
