Fig. 7: Exosomal miR-146a-5p mitigates liver fibrosis in vivo. | Cell Death Discovery

Fig. 7: Exosomal miR-146a-5p mitigates liver fibrosis in vivo.

From: Hepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell EMT process: a crosstalk between hepatocytes and hepatic stellate cells

Fig. 7

CCl4-induced mice were treated with exosomes (40 μg) from hepatocytes with miR-146a-5p mimic transfection. A The exosomes treatment strategy for CCl4-induced liver fibrosis in vivo. B HE staining. Scale bar, 100 μm. C, D Levels of ALT, AST and Hyp. Cont, the control group; CCl4, the CCl4 group; CCl4+exo-miR-NC, CCl4 mice after exosomes from hepatocytes with miR-NC transfection; CCl4+exo-miR-146a-5p mimic, CCl4 mice after exosomes from hepatocytes with miR-146a-5p mimic transfection. Each value is the mean ± SD of six experiments. ***p < 0.001.

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