Fig. 4: Biological interpretation of the ISO-specific differentially expressed genes after exposure of hiPSCs (IMR90) to ISO, THD and VPA at day1. | Cell Death Discovery

Fig. 4: Biological interpretation of the ISO-specific differentially expressed genes after exposure of hiPSCs (IMR90) to ISO, THD and VPA at day1.

From: Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells

Fig. 4

A, B The Venn diagrams shows the number of down-regulated and up-regulated SPS (log2 fold change > 1; adjusted p‐value < 0.05), respectively induced by the selected compounds. C, D Metascape analysis for specific ISO-induced downregulated and upregulated SPS, respectively. Analysis shows the statistically enriched BPs and pathways as colored by the p values. E, F The Venn diagrams shows the number of down-regulated and up-regulated SPS (log2 fold change > 1; adjusted p‐value < 0.05), respectively induced by the selected compounds. G, H Metascape analysis for specific ISO-induced downregulated and upregulated SPS, respectively. Analysis shows the statistically enriched BPs and pathways as colored by the p values.

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