Table 1 Compounds, abbreviations, C_max concentrations, beating profile and CDI score for non teratogens and teratogens.

From: Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells

Compound	Abbreviation	Tested concentration [µM]	Beating^a	CDI score
Compound	Abbreviation	1-fold C_max^b	Beating^a	CDI score
Non-teratogens
Ampicillin	AMP	107	Yes	0.1^c
Ascorbic acid	ASC	200	Yes	0
Buspirone	BSP	0.0244	Yes	0
Chlorpheniramine	CPA	0.0304	Yes	0
Dextromethorphan	DEX	0.15	Yes	0
Diphenhydramine	DPH	0.3	Yes	0
Doxylamine	DOA	0.38	Yes	0.03
Famotidine	FAM	1.06	Yes	0
Folic acid	FOA	0.38	Yes	0.03
Levothyroxine	LEV	0.077	Yes	0.03
Liothyronine	LIO	0.00307	Yes	0.06^d
Magnesium (chloride)	MAG	1200	Yes	0
Methicillin	MET	140	Yes	0
Ranitidine	RAN	0.8	Yes	0
Retinol	RET	1	Yes	0
Sucralose	SUC	2.5	Yes	0.2
Teratogens
9-cis-Retinoic acid	9RA	1	No	1
Acitretin	ACI	1.2	No	1
Isotretinoin	ISO	1.7	No	1
Atorvastatin	ATO	0.54	Yes	0
Carbamazepine	CMZ	19	Yes	0.03
Entinostat	ENT	0.2	Yes	0.2^e
Favipiravir	FPV	382	Yes	0
Leflunomide	LFL	370	Yes	0.3^f
Lithium (chloride)	LTH	1000	Yes	0.2^g
Methotrexate	MTX	1	Yes	0.2
Methylmercury	MEM	0.02	Yes	0.1^h
Paroxetine	PAX	1.2	Yes	0.2ⁱ
Teriflunomide	TER	370	Yes	0.3^j
Thalidomide	THD	3.9	Yes	0.3
Trichostatin A	TSA	0.01	Yes	0.1^k
Valproic acid	VPA	600	Yes	0.4
Vismodegib	VIS	20	Yes	0

^aYes, if beating was observed; No, if beating was not observed.
^bΥes^, if on day 14 was observed beating cardiomyocytes; No, if on day 14 were not observed any beating cardiomyocytes. The CDI score is defined as Cardiotoxicity Developmental Index. This index has a maximal value of 1, which is reached when all 31 genes from (Fig. 5E) are deregulated by a compound; likewise, it has a minimal value of 0 if no gene is deregulated. The CDI score is calculated only on the hiPSC-SBAD2 cells. The beating and cytoxocity refers to hiPSC-IMR90 as well as hiPSC-SBAD2 indicate a different deregulation pattern as the retinoinds and the 31 ‘’gold standard” genes.
^cTotal 3 out 31, 2 downregulated instead of up regulated like in retinoids.
^dTotal 7 out 31, 1 downregulated instead of up regulated like in retinoids.
^eTotal 6 out 31, 2 downregulated instead of up regulated like in retinoids, 3 upregulated instead of being downregulated like in retinoinds.
^fTotal 10 out 31, 4 downregulated instead of up regulated like in retinoids, 1 is upregulated instead of being downregulated like in retinoinds.
^gTotal 7 out 31, 5 downregulated instead of up regulated like in retinoids, 1 is upregulated instead of being downregulated like in retinoinds.
^hTotal 4 out 31, 3 downregulated instead of up regulated like in retinoids, 1 is upregulated instead of being downregulated like in retinoinds.
ⁱTotal 6 out 31, 1 downregulated instead of up regulated like in retinoids.
^jTotal 8 out 31, 3 downregulated instead of up regulated like in retinoids.
^kTotal 4 out 31, 1 downregulated instead of up regulated like in retinoids, 1 is upregulated instead of being downregulated like in retinoinds.

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Table 1 Compounds, abbreviations, C_max concentrations, beating profile and CDI score for non teratogens and teratogens.

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