Fig. 6: AURKA mediated the function of TIALD in metastasis inhibition. | Cell Death Discovery

Fig. 6: AURKA mediated the function of TIALD in metastasis inhibition.

From: LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

Fig. 6

A Representative images and quantification results of transwell cell migration and invasion assay in SMMC-7721 cells stably transfected with shTIALD, shAURKA, and co-transfected shTIALD and shAURKA. B Representative images and quantification results of transwell cell migration and invasion assay in SNU449 cells stably transfected with TIALD, AURKA, and co-transfected TIALD and AURKA. C Western blotting analysis of EMT-associated markers in SMMC-7721 and SNU449 cells as indicated. D Representative images and quantification results of transwell cell migration and invasion assay in SMMC-7721 cells stably transfected with shTIALD and treated with Alisertib (10 μM, 12 h). E, F Representative images and quantification data of metastatic nodules in the lung tissues of mice. Stable cell lines of TIALD knockdown were injected by tail vein in B-NDG mice and treated with Alisertib as indicated.

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