Fig. 7: The METTL16/TIALD/AURKA axis contribute to HCC metastasis. | Cell Death Discovery

Fig. 7: The METTL16/TIALD/AURKA axis contribute to HCC metastasis.

From: LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

Fig. 7

A, B Representative images and quantification results of transwell cell migration and invasion assay in SMMC-7721 cells and SNU449 cells transfected with vector as indicated. C Summary of the mechanism by which METTL16 mediated m6A methylation was involved in the downregulation of TIALD by facilitates its RNA degradation, TIALD bind to AURKA and facilitate its degradation through the lysosomal pathway, thus inhibited EMT and metastasis of HCC, lastly, METTL16/TIALD/AURKA axis contributed to HCC metastasis.

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